Inhibition of Catalase Activity by Isoniazid and the Effect of Vitamin B6.

Inhibition of Catalase Activity by Isoniazid and the Effect of Vitamin B6.

Summary The inhibition by INH of mammalian catalase and mycobacterial catalase of representative strains was markedly enhanced by divalent copper ions. Pyridoxal hydrochloride completely reversed the inhibitory action of the INH-Cu++ complex. This antagonism apparently was due to chemical removal of...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1963-01, Vol.112 (1), p.30-33
Hauptverfasser: Hawkins, Jean E., Steenken, William
Format: Artikel
Sprache:eng
Schlagworte:
Catalase
Copper
Humans
Isoniazid
Old Medline
Oxidation-Reduction
Pyridoxine
Vitamin B 6
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Zusammenfassung:Summary The inhibition by INH of mammalian catalase and mycobacterial catalase of representative strains was markedly enhanced by divalent copper ions. Pyridoxal hydrochloride completely reversed the inhibitory action of the INH-Cu++ complex. This antagonism apparently was due to chemical removal of the inhibitor by precipitation. Pyridoxamine and pyridoxine, which respectively have slight and no effect in vitro against the antituberculosis activity of INH, did not significantly affect the INH-metal ion inhibition of mycobacterial catalase.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-112-27941