Permeability of sublingual mucosa to organic molecules. Limited role of sublingual absorption in aerosol vaccinations

131I labelled tetanus anatoxin was placed in vivo, in the sublingual area in the rat. The radioactivity appearing in blood was insignificant, even after that the disappearance rate in reference animal had been taken into account. It is concluded that immunisation with aerosols is fundamentally carri...

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Veröffentlicht in:	Comptes rendus des seances de la Societe de biologie et de ses filiales 1975, Vol.169 (5), p.1227-1231
Hauptverfasser:	Buclon, M, Bourdier, R, Cartier, M, Fontanges, R
Format:	Artikel
Sprache:	fre
Schlagworte:	Aerosols Animals Biological Transport Injections, Intravenous Male Mouth Floor - metabolism Mucous Membrane - metabolism Rats Tetanus Toxoid - administration & dosage Tetanus Toxoid - blood Tetanus Toxoid - metabolism Thyroid Gland - metabolism Vaccination
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Zusammenfassung:	131I labelled tetanus anatoxin was placed in vivo, in the sublingual area in the rat. The radioactivity appearing in blood was insignificant, even after that the disappearance rate in reference animal had been taken into account. It is concluded that immunisation with aerosols is fundamentally carried out through the respiratory tract.
ISSN:	0037-9026