beta.-Lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides

A series of penicillin derivatives of quinoxaline di-N-oxide carboxylic acids was prepared. These compounds were prepared from the acid chlorides and mixed anhydrides of the quinoxaline di-N-oxides. The compounds prepared exhibited minimal antibacterial activity against gram-negative organisms.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1976-02, Vol.19 (2), p.330-333
Hauptverfasser:	Edwards, M. L, Bambury, R. E, Ritter, H. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic N-Oxides - chemical synthesis Cyclic N-Oxides - pharmacology Cyclic N-Oxides - therapeutic use Mice Microbial Sensitivity Tests Penicillins - chemical synthesis Penicillins - pharmacology Penicillins - therapeutic use Proteus Infections - drug therapy Proteus mirabilis Pseudomonas aeruginosa Pseudomonas Infections - drug therapy Quinoxalines - chemical synthesis Quinoxalines - pharmacology Quinoxalines - therapeutic use Salmonella paratyphi B - drug effects Staphylococcus aureus - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of penicillin derivatives of quinoxaline di-N-oxide carboxylic acids was prepared. These compounds were prepared from the acid chlorides and mixed anhydrides of the quinoxaline di-N-oxides. The compounds prepared exhibited minimal antibacterial activity against gram-negative organisms.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00224a026