ASCORBIC ACID IN CHOLESTEROL AND BILE ACID METABOLISM

Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slow...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1975-09, Vol.258 (1), p.410-421
1. Verfasser:	Ginter, Emil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Ascorbic Acid - administration & dosage Ascorbic Acid - pharmacology Ascorbic Acid Deficiency - complications Ascorbic Acid Deficiency - metabolism Bile Acids and Salts - metabolism Cholesterol - metabolism Cholesterol - pharmacology Cholesterol, Dietary Female Guinea Pigs Humans Hypercholesterolemia - etiology Kinetics Liver - drug effects Liver - metabolism Male Middle Aged Spleen - drug effects Spleen - metabolism
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Beschreibung
Zusammenfassung:	Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slows the release of cholesterol from the circulation. Ascorbic acid probably intervenes into the biosynthesis of bile acids at the stage of 7 alpha-hydroxylation of the cholesterol nucleus. High doses of ascorbic acid significantly stimulate cholesterol transformation to bile acids in guinea pigs and decrease plasma cholesterol concentration in humans.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.1975.tb29299.x