Terminal Oxidation in the Regulation of Heme Biosynthesis

Terminal Oxidation in the Regulation of Heme Biosynthesis

Turnover of the tricarboxylic acid cycle and the rate of succinyl-coenzyme A formation may be important factors in the regulation of heme biosynthesis in liver homogenate. Acting as hydrogen acceptor, acetoacetate appears to have a unique role in influencing these metabolic processes.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1963-06, Vol.140 (3573), p.1326-1327
Hauptverfasser: Onisawa, Jinichi, Labbe, Robert F.
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
Acetoacetates
Acyl Coenzyme A
Biosynthesis
Citric Acid Cycle
Heme
Liver
Malonates
Old Medline
Oxidation
Oxidation-Reduction
Physiological regulation
Porphyrias
Porphyrins
Protein synthesis
Radioactive decay
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Beschreibung
Zusammenfassung:Turnover of the tricarboxylic acid cycle and the rate of succinyl-coenzyme A formation may be important factors in the regulation of heme biosynthesis in liver homogenate. Acting as hydrogen acceptor, acetoacetate appears to have a unique role in influencing these metabolic processes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.140.3573.1326