Potential Anti-cancer Agents. XI. Synthesis of 4- and 5-Azidopyridazine 1-Oxide

Potential Anti-cancer Agents. XI. Synthesis of 4- and 5-Azidopyridazine 1-Oxide

Reaction of 3, 4, 5-trichloropyridazine (IV) with sodium methoxide was examined. 4-Azidopyridazine 1-oxide (XVII) and 5-azidopyridazine 1-oxide (XXI) were synthesized from corresponding hydrazino compounds (XIV, XX) with nitrous acid, and XVII was also derived from 4-chloropyridazine 1-oxide (XIII)...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1963/08/25, Vol.11(8), pp.1059-1064
Hauptverfasser: Itai, Takanobu, Kamiya, Shozo
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemical synthesis
Oxides
Pyridazines - chemical synthesis
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Zusammenfassung:Reaction of 3, 4, 5-trichloropyridazine (IV) with sodium methoxide was examined. 4-Azidopyridazine 1-oxide (XVII) and 5-azidopyridazine 1-oxide (XXI) were synthesized from corresponding hydrazino compounds (XIV, XX) with nitrous acid, and XVII was also derived from 4-chloropyridazine 1-oxide (XIII) with sodium azide.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.11.1059