Studies on the Synthesis of New Antimicrobials. I. Synthesis of 2, 5-Dichloroaniline Derivatives and their Some Antibacterial Activities

Studies on the Synthesis of New Antimicrobials. I. Synthesis of 2, 5-Dichloroaniline Derivatives and their Some Antibacterial Activities

Twentyfour of new N-derivatives of 2, 5-dichloroaniline, 2, 5-dichloro-4-bromo-aniline and 2, 5-dichloro-4-thiocyanatoaniline were synthesized in order to investigate the potential antimicrobial activity. Among them, 2-hydroxy-5-bromobenzoyl derivatives were found to give strong antibacterial activi...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1962/12/25, Vol.10(12), pp.1226-1232
Hauptverfasser: Kimura, Ryuichi, Yabuuchi, Takahiro, Hisaki, Masakatsu, Sugimoto, Hideki, Ohyama, Akio, Mochida, Kooichi
Format: Artikel
Sprache:eng
Schlagworte:
Aniline Compounds
Anti-Bacterial Agents
Anti-Infective Agents
Escherichia coli
Old Medline
Staphylococcus
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Zusammenfassung:Twentyfour of new N-derivatives of 2, 5-dichloroaniline, 2, 5-dichloro-4-bromo-aniline and 2, 5-dichloro-4-thiocyanatoaniline were synthesized in order to investigate the potential antimicrobial activity. Among them, 2-hydroxy-5-bromobenzoyl derivatives were found to give strong antibacterial activities on Staph. aureus in vitro.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.10.1226