Urine Concentration and Dilution: Effect on Red Cell Survival

Conclusion Survival time of 51Cr-labeled red cells was determined in dogs subjected to water restriction excreting concentrated urine and again following a 6-week period of ad lib. water intake. During water restriction, RBC survival was reduced to one-seventh of normal. In rats with untreated diabe...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1975-11, Vol.150 (2), p.295-298
Hauptverfasser:	Alexander, Carl S., Swaim, William R., Garcia, Mario C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dehydration Diabetes Insipidus - physiopathology Diabetes Insipidus - urine Dogs Erythrocyte Aging Half-Life Kidney Concentrating Ability Rats Water Deprivation
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Zusammenfassung:	Conclusion Survival time of 51Cr-labeled red cells was determined in dogs subjected to water restriction excreting concentrated urine and again following a 6-week period of ad lib. water intake. During water restriction, RBC survival was reduced to one-seventh of normal. In rats with untreated diabetes insipidus, 51Cr RBC survival was reduced 30% as compared to the pitressin-treated state. It appears that RBC survival may be influenced by osmotic stress associated with the state of urine concentration and dilution.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-150-39022