The relationship between collagen scaffold cross-linking agents and neutrophils in the foreign body reaction

Abstract In order to get more insight into the role of neutrophils on the micro-environment and consequently on macrophages in the foreign body reaction in mice, we investigated the fate of the two differently cross-linked dermal sheep collagen disks (glutaraldehyde = GDSC, hexamethylenediisocyanate...

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Veröffentlicht in:	Biomaterials 2010-12, Vol.31 (35), p.9192-9201
Hauptverfasser:	Ye, Qingsong, Harmsen, Martin C, van Luyn, Marja J.A, Bank, Ruud A
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Collagen - chemistry Cross-Linking Reagents - chemistry Cross-Linking Reagents - pharmacology Dentistry Foreign body reaction Foreign-Body Reaction - chemically induced Foreign-Body Reaction - immunology Foreign-Body Reaction - metabolism Giant cell formation Giant Cells - metabolism Glutaral - chemistry Glutaral - pharmacology Immunohistochemistry Interferon-gamma Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-13 - metabolism Isocyanates - chemistry Isocyanates - pharmacology Male Matrix metalloproteinase Mice Mice, Inbred C57BL Neutrophil Infiltration - drug effects Neutrophils Neutrophils - drug effects Neutrophils - immunology Phagocytosis Phagocytosis - drug effects Sheep Tissue Inhibitor of Metalloproteinase-1 - metabolism
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