Protective Effect of Intravenous Mumps Vaccine in Early Neonatal Mice.

Summary A striking degree of protection from fatal mumps encephalitis is afforded mice if they are injected intravenously with mumps vaccine when less than 4 hours old. A less marked but very significant degree of protection is also afforded by influenza vaccine used in this same way, but none at all using the formalin diluent alone. With advancing age above the four-hour group this sparing effect diminishes. These results may be due to combined effects of viral interference and antibody production.