Whence comes Trypanosoma lewisi antigen which induces ablastic antibody: Studies in the occult?

I propose that trypanosomes have three antigen compartments: the intracellular, plasma membrane, and extracellular compartments. The intracellular antigens are released when trypanosomes lyse; the plasma membrane antigens are the structural or transport components of the plasma membrane and the adhe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experimental parasitology 1975-12, Vol.38 (3), p.350-356
1. Verfasser: Bawden, Monte P.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:I propose that trypanosomes have three antigen compartments: the intracellular, plasma membrane, and extracellular compartments. The intracellular antigens are released when trypanosomes lyse; the plasma membrane antigens are the structural or transport components of the plasma membrane and the adhering surface coat; the extracellular antigens are secreted by the trypanosomes. I further suggest that ablastinogen, the Trypanosoma lewisi antigen which induces ablastic antibody, is a plasma membrane antigen, and that the T. lewisi trypanocidal antigens are in the surface coat. The T. lewisi exoantigens described by D'Alesandro (1972) are, as he stated, different from ablastinogen and trypanocidal antigens. I suggest that the exoantigens are secreted extracellular antigens. Data from the literature are presented to support the hypothesis, and an experimental protocol to test the hypothesis is outlined.
ISSN:0014-4894
1090-2449
DOI:10.1016/0014-4894(75)90121-6