Effect of lysosomal cationic proteins from polymorphonuclear leukocytes upon the fibrinogen and fibrinolysis system

Heterogeneous lysosomal cationic proteins from PMN leukocytes contain substances exhibiting in vitro (1) Anticoagulant activity; (2) Fibrinogen precipitating activity; (3) Fibrin polymerizing-precipitating activity; (4) Plasminogen activator activity; and (5) Direct fibrinogenolytic and fibrinolytic...

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Veröffentlicht in:	Thrombosis research 1975-10, Vol.7 (4), p.543-554
Hauptverfasser:	Saba, Hussain I., Herion, John C., Walker, Richard I., Roberts, Harold R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminocaproates - pharmacology Animals Blood Coagulation - drug effects Fibrin Fibrin Fibrinogen Degradation Products - analysis Fibrinogen Fibrinolysis Hydrogen-Ion Concentration Leukocytes - analysis Lysosomes - analysis Peptide Hydrolases - isolation & purification Peptide Hydrolases - metabolism Plasminogen - pharmacology Plasminogen Activators - isolation & purification Plasminogen Activators - pharmacology Protease Inhibitors Proteins - pharmacology Rabbits Trypsin Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:	Heterogeneous lysosomal cationic proteins from PMN leukocytes contain substances exhibiting in vitro (1) Anticoagulant activity; (2) Fibrinogen precipitating activity; (3) Fibrin polymerizing-precipitating activity; (4) Plasminogen activator activity; and (5) Direct fibrinogenolytic and fibrinolytic activity. The anticoagulant activity is not blocked by serum or SBTI. The plasminogen activator, stable at acid pH, is blocked by EACA. An acid-labile direct fibrinogenolytic and fibrinolytic activity, stable at neutral pH, is incompletely blocked by the plasmin inhibitor, SBTI.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(75)90101-2