Troponin C in brain

THE tropomyosin–troponin complex renders actomyosin from vertebrate skeletal muscle calcium sensitive. Troponin itself consists of three subunits: troponin I (TNI), troponin C (TNC) and troponin T (TNT) 1 . Pure TNI (24,000-dalton subunit) inhibits the actin–myosin interaction irrespective of calciu...

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Veröffentlicht in:	Nature (London) 1975-11, Vol.258 (5532), p.260-262
Hauptverfasser:	FINE, RICHARD, LEHMAN, WILLIAM, HEAD, JAMES, BLITZ, ALAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Animals Brain Chemistry Chick Embryo Humanities and Social Sciences letter multidisciplinary Muscle Proteins - analysis Science Science (multidisciplinary) Troponin - analysis Troponin - isolation & purification Troponin - metabolism
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Beschreibung
Zusammenfassung:	THE tropomyosin–troponin complex renders actomyosin from vertebrate skeletal muscle calcium sensitive. Troponin itself consists of three subunits: troponin I (TNI), troponin C (TNC) and troponin T (TNT) 1 . Pure TNI (24,000-dalton subunit) inhibits the actin–myosin interaction irrespective of calcium concentration. TNC (18,000-dalton subunit) binds calcium and releases the TNI imposed inhibition. TNT (37,000-dalton subunit) attaches the subunit complex to tropomyosin. Actin, myosin and tropomyosin have been isolated and characterised from a number of non-muscle cells 2,3 . We now describe the isolation and characterisation of a protein from chick embryo brain which is very similar to muscle TNC.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/258260a0