Renin, A Physiologic Regulator of Renal Hemodynamics?

1. Injections of hog renin and formation of antirenin in the dog will prevent or reduce the elevation of blood pressure associated with constriction of the renal arteries, but will not affect the systemic blood pressure in the normal animal.2. The kidneys of both the normal and renal artery constricted animal respond with an increase in renin content during hog-renin injections which correlates closely with the serum antirenin titer.3. The juxtaglomerular cell appears to be the site of renin formation and in this location may affect postglomerular vascular resistance.4. Dogs with high titers of antirenin apparently have a reduced capacity to respond to an alteration in postglomerular resistance.5. It is proposed that renin formation is controlled normally by a pressure-sensitive feedback mechanism operating across the glomerulus between the juxtaglomerular cell and postglomerular resistance.