The distribution of various water soluble radioactive metalloporphyrins in tumor bearing mice

The distribution of various water soluble radioactive metalloporphyrins in tumor bearing mice

The distribution of a variety of water soluble 109Pd and 64Cu porphyrins were studied in mice bearing three types of tumors. While the metalloporphyrins are found to have an affinity for neoplastic tissue, substantial extra-tumor concentrations are also noted. Although this limits their value as spe...

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Veröffentlicht in:Bioinorg. Chem.; (United States) 1975, Vol.5 (1), p.87-92
Hauptverfasser: Hambright, P., Fawwaz, R., Valk, P., McRae, J., Bearden, A.J.
Format: Artikel
Sprache:eng
Schlagworte:
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
Carcinoma - metabolism
Copper - metabolism
COPPER 64
COPPER ISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
Lead - metabolism
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
Neoplasms, Experimental - metabolism
Neuroblastoma - metabolism
NUCLEI
ODD-ODD NUCLEI
Organ Specificity
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
Organometallic Compounds - metabolism
PALLADIUM 109
PALLADIUM ISOTOPES
PORPHYRINS
Porphyrins - metabolism
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIOISOTOPES
RODENTS
Sarcoma, Experimental - metabolism
Structure-Activity Relationship
THERAPY
TISSUE DISTRIBUTION
VERTEBRATES
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Zusammenfassung:The distribution of a variety of water soluble 109Pd and 64Cu porphyrins were studied in mice bearing three types of tumors. While the metalloporphyrins are found to have an affinity for neoplastic tissue, substantial extra-tumor concentrations are also noted. Although this limits their value as specific tumor imaging agents, their use in localized therapy is discussed.
ISSN:0006-3061
1873-3190
DOI:10.1016/S0006-3061(00)80224-0