Circular dichroism and infrared studies of substance P and C-terminal analogs

Circular dichroism and infrared studies of substance P and C-terminal analogs

Substance P and its C-terminal sequences (tetra- to decapeptide) have been studied by circular dichroism and infrared absorption in aqueous solution. The spectral patterns indicate the presence of intramolecular hydrogen bonds in substance P whereas octapeptide (VIII) in particular exhibits intermol...

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Veröffentlicht in:Biochemical and biophysical research communications 1975-10, Vol.66 (4), p.1447-1453
Hauptverfasser: Mehlis, B., Böhm, S., Becker, M., Bienert, M.
Format: Artikel
Sprache:eng
Schlagworte:
Circular Dichroism
Oligopeptides
Protein Conformation
Spectrophotometry, Infrared
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Zusammenfassung:Substance P and its C-terminal sequences (tetra- to decapeptide) have been studied by circular dichroism and infrared absorption in aqueous solution. The spectral patterns indicate the presence of intramolecular hydrogen bonds in substance P whereas octapeptide (VIII) in particular exhibits intermolecular association over a wide range of concentration.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(75)90521-5