Effect of Anti-inflammatory Agents on Accelerated Granuloma Formation in Rats

Effects of steroidal and non-steroidal anti-inflammatory agents on the accelerated granuloma formation in rats, which was induced by the dual implantation of felt-pellets, were compared with effects on the usual granuloma formation (one time implantation of felt-pellet). The ID30 % value of anti-granuloma activity of each agent in the usual method was as follows : dexamethasone 0.03mg/kg/day, indomethacin 1.4 mg/kg/day, prednisolone 2.5mg/kg/day, flufenamic acid 18.5 mg/kg/day, phenylbutazone 20.0 mg/kg/day and Aspirin 700 mg/kg/day, p. o. However, indomethacin (2 and 3 mg/kg/day), phenylbutazone (30 and 100 mg/kg/day) and Aspirin (600 mg/kg/day) did not show any signific anti-granuloma activity on the accelerated granuloma formation, and these inhibitory activities were less than 20%. Flufenamic acid showed the activity at 60 mg/kg/day, but did not at 30 mg/kg/day. On the other hand, prednisolone inhibited by the same degree both usual and accelerated granuloma formations at 3 and 10 mg/kg/day, and dexamethasone showed more potent inhibitory activity on the accelerated granuloma formation than that on the usual granuloma formation. These results suggest that the mode of anti-granuloma action of steroidal anti-inflammatory agents may be different from those of non-steroidal anti-inflammatory agents.