Erythrocyte δ-aminolevulinic acid dehydrase activity in thalassemia major and sickle-cell anemia

Erythrocyte δ-aminolevulinic acid dehydrase activity in thalassemia major and sickle-cell anemia

An enzyme deficiency has been postulated to account for the defect in hemoglobin synthesis in certain hereditary anemias. The enzyme necessary for the conversion of δ-aminolevulinic acid to porphobilinogen, an obligatory step in heme synthesis, was assayed. The values obtained from the circulating e...

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Veröffentlicht in:Biochimica et biophysica acta 1962-04, Vol.58 (2), p.291-293
Hauptverfasser: Feldman, Felix, Lichtman, Herbert C.
Format: Artikel
Sprache:eng
Schlagworte:
Aminolevulinic Acid
Anemia
Anemia, Sickle Cell - blood
beta-Thalassemia - blood
Erythrocytes - metabolism
Humans
Hydro-Lyases - blood
Old Medline
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Zusammenfassung:An enzyme deficiency has been postulated to account for the defect in hemoglobin synthesis in certain hereditary anemias. The enzyme necessary for the conversion of δ-aminolevulinic acid to porphobilinogen, an obligatory step in heme synthesis, was assayed. The values obtained from the circulating erythrocyte of patients with thalassemia and sickle-cell anemia were higher than normal.
ISSN:0006-3002
1878-2434
DOI:10.1016/0006-3002(62)91011-9