Renal Electrolyte Effects of Synthetic 18-Hydroxylated Steroids in Adrenalectomized Rats

Summary Several synthetic 18-hydroxy-lated steroids lacking oxygen at carbon 11 were tested for mineralocorticoid properties in acute studies using adrenalectomized rats. A multiple dose assay with DCA described relative potencies of 4, 8 and 5% parenterally for 18-OH-DCA by the criteria of Na reten...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1962-04, Vol.109 (4), p.982-985
Hauptverfasser:	Kagawa, C. M., Pappo, Raphael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - pharmacology Animals Electrolytes Hydroxylation Old Medline Potassium - urine Progesterone - analogs & derivatives Rats Sodium - urine Steroids - pharmacology
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Zusammenfassung:	Summary Several synthetic 18-hydroxy-lated steroids lacking oxygen at carbon 11 were tested for mineralocorticoid properties in acute studies using adrenalectomized rats. A multiple dose assay with DCA described relative potencies of 4, 8 and 5% parenterally for 18-OH-DCA by the criteria of Na retention, K loss and reduction of the Na/K ratio in the urine. Approximately the same order of potency was found for the alcohol derivative, 18-OH-DOC. 18-OH-Progesterone was ineffective as a mineralocorticoid. No significant anti-mineralocorticoid activity was found with 18-OH-progesterone or 18-OH-DCA.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-109-27398