THE QUANTITATIVE DETERMINATION OF GRISEOFULVIN BY GAS CHROMATOGRAPHY (ECD-GC)

THE QUANTITATIVE DETERMINATION OF GRISEOFULVIN BY GAS CHROMATOGRAPHY (ECD-GC)

Serum and organ griseofulvin levels in guinea pigs and serum levels in patients who received a prolonged oral administration of griseofulvin were determined gas-chromatographically. In guinea pigs liver showed the highest concentration of griseofulvin, followed by kidney and serum in the decreasing...

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Veröffentlicht in:Japanese journal of antibiotics 1975/10/25, Vol.28(5), pp.665-668
Hauptverfasser: SUENAGA, YOSHINORI, YASUKAWA, NORIHIRO
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Aged
Animals
Brain Chemistry
Chromatography, Gas
Griseofulvin - administration & dosage
Griseofulvin - analysis
Griseofulvin - blood
Guinea Pigs
Humans
Kidney - analysis
Liver - analysis
Lung - analysis
Middle Aged
Skin - analysis
Time Factors
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Beschreibung
Zusammenfassung:Serum and organ griseofulvin levels in guinea pigs and serum levels in patients who received a prolonged oral administration of griseofulvin were determined gas-chromatographically. In guinea pigs liver showed the highest concentration of griseofulvin, followed by kidney and serum in the decreasing order. The skin levels were 0.16-1.51μg/g with a dose of 30mg/kg. In humans it was proved that griseofulvin did not cause any accumulation in the serum with a dosage of 500mg/day.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.28.665