Identification and Quantitation of Impurities in Dapsone Preparations
Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4′‐diamino‐diphenyl sulfone and 4‐aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4′‐diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1975-07, Vol.64 (7), p.1205-1207 |
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| container_end_page | 1207 |
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| container_issue | 7 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 64 |
| creator | Gordon, G.R. Ghoul, D.C. Peters, J.H. |
| description | Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4′‐diamino‐diphenyl sulfone and 4‐aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4′‐diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high‐pressure liquid chromatography. |
| doi_str_mv | 10.1002/jps.2600640717 |
| format | Article |
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Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high‐pressure liquid chromatography.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600640717</identifier><identifier>PMID: 1151684</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>and quantitation ; Chromatography, Thin Layer ; Dapsone - analysis ; dapsone impurities in pharmaceutical preparations ; Dapsone-isolation ; Dapsone—isolation, identification, and quantitation, pharmaceutical preparations ; Fluorometry ; High-pressure liquid chromatography-determination ; High‐pressure liquid chromatography—determination, dapsone impurities in pharmaceutical preparations ; identification ; Methods ; pharmaceutical preparations ; Spectrophotometry, Ultraviolet ; Sulfones - isolation & purification ; Tablets - analysis ; TLC-determination ; TLC—determination, dapsone impurities in pharmaceutical preparations</subject><ispartof>Journal of pharmaceutical sciences, 1975-07, Vol.64 (7), p.1205-1207</ispartof><rights>1975 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4277-fc89cc5a0618c2097d55531beb0803100b30d430c9cac543269ccb06bd5d4d8a3</citedby><cites>FETCH-LOGICAL-c4277-fc89cc5a0618c2097d55531beb0803100b30d430c9cac543269ccb06bd5d4d8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600640717$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600640717$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1151684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gordon, G.R.</creatorcontrib><creatorcontrib>Ghoul, D.C.</creatorcontrib><creatorcontrib>Peters, J.H.</creatorcontrib><title>Identification and Quantitation of Impurities in Dapsone Preparations</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4′‐diamino‐diphenyl sulfone and 4‐aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4′‐diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high‐pressure liquid chromatography.</description><subject>and quantitation</subject><subject>Chromatography, Thin Layer</subject><subject>Dapsone - analysis</subject><subject>dapsone impurities in pharmaceutical preparations</subject><subject>Dapsone-isolation</subject><subject>Dapsone—isolation, identification, and quantitation, pharmaceutical preparations</subject><subject>Fluorometry</subject><subject>High-pressure liquid chromatography-determination</subject><subject>High‐pressure liquid chromatography—determination, dapsone impurities in pharmaceutical preparations</subject><subject>identification</subject><subject>Methods</subject><subject>pharmaceutical preparations</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Sulfones - isolation & purification</subject><subject>Tablets - analysis</subject><subject>TLC-determination</subject><subject>TLC—determination, dapsone impurities in pharmaceutical preparations</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLxDAQh4Mouj6u3oSevHWdtE3SHsXHuirq4usY0mQK0d22Jq2P_95oRfEgngZmvt8P5iNkm8KYAiR7D60fJxyAZyCoWCIjyhKIOVCxTEYBSOKUZcUaWff-AQIGjK2SVUoZ5Xk2IkdTg3VnK6tVZ5s6UrWJZr0Kq25YNFU0XbS9s51FH9k6OlStb2qMrhy2yn1CfpOsVGrucetrbpDb46Obg5P4_HIyPdg_j3WWCBFXOi-0Zgo4zXUChTCMsZSWWEIOaXinTMFkKehCK82yNOEBL4GXhpnM5CrdILtDb-uapx59JxfWa5zPVY1N72WeFELwIgvgeAC1a7x3WMnW2YVyb5KC_PAmgzf54y0Edr6a-3KB5gcfRIV7Mdxf7Bzf_mmTp1fXv7rjIWt9h6_fWeUeJRepYPL-YiJnZ3f5ZHbN5Gng84HHoPLZopNeW6w1GutQd9I09q833gGJx5tX</recordid><startdate>197507</startdate><enddate>197507</enddate><creator>Gordon, G.R.</creator><creator>Ghoul, D.C.</creator><creator>Peters, J.H.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197507</creationdate><title>Identification and Quantitation of Impurities in Dapsone Preparations</title><author>Gordon, G.R. ; Ghoul, D.C. ; Peters, J.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4277-fc89cc5a0618c2097d55531beb0803100b30d430c9cac543269ccb06bd5d4d8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>and quantitation</topic><topic>Chromatography, Thin Layer</topic><topic>Dapsone - analysis</topic><topic>dapsone impurities in pharmaceutical preparations</topic><topic>Dapsone-isolation</topic><topic>Dapsone—isolation, identification, and quantitation, pharmaceutical preparations</topic><topic>Fluorometry</topic><topic>High-pressure liquid chromatography-determination</topic><topic>High‐pressure liquid chromatography—determination, dapsone impurities in pharmaceutical preparations</topic><topic>identification</topic><topic>Methods</topic><topic>pharmaceutical preparations</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Sulfones - isolation & purification</topic><topic>Tablets - analysis</topic><topic>TLC-determination</topic><topic>TLC—determination, dapsone impurities in pharmaceutical preparations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gordon, G.R.</creatorcontrib><creatorcontrib>Ghoul, D.C.</creatorcontrib><creatorcontrib>Peters, J.H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gordon, G.R.</au><au>Ghoul, D.C.</au><au>Peters, J.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and Quantitation of Impurities in Dapsone Preparations</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1975-07</date><risdate>1975</risdate><volume>64</volume><issue>7</issue><spage>1205</spage><epage>1207</epage><pages>1205-1207</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4′‐diamino‐diphenyl sulfone and 4‐aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4′‐diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high‐pressure liquid chromatography.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>1151684</pmid><doi>10.1002/jps.2600640717</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1975-07, Vol.64 (7), p.1205-1207 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82977694 |
| source | MEDLINE; Wiley Journals; Alma/SFX Local Collection |
| subjects | and quantitation Chromatography, Thin Layer Dapsone - analysis dapsone impurities in pharmaceutical preparations Dapsone-isolation Dapsone—isolation, identification, and quantitation, pharmaceutical preparations Fluorometry High-pressure liquid chromatography-determination High‐pressure liquid chromatography—determination, dapsone impurities in pharmaceutical preparations identification Methods pharmaceutical preparations Spectrophotometry, Ultraviolet Sulfones - isolation & purification Tablets - analysis TLC-determination TLC—determination, dapsone impurities in pharmaceutical preparations |
| title | Identification and Quantitation of Impurities in Dapsone Preparations |
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