Identification and Quantitation of Impurities in Dapsone Preparations

Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4′‐diamino‐diphenyl sulfone and 4‐aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4′‐diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1975-07, Vol.64 (7), p.1205-1207
Hauptverfasser:	Gordon, G.R., Ghoul, D.C., Peters, J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	and quantitation Chromatography, Thin Layer Dapsone - analysis dapsone impurities in pharmaceutical preparations Dapsone-isolation Dapsone—isolation, identification, and quantitation, pharmaceutical preparations Fluorometry High-pressure liquid chromatography-determination High‐pressure liquid chromatography—determination, dapsone impurities in pharmaceutical preparations identification Methods pharmaceutical preparations Spectrophotometry, Ultraviolet Sulfones - isolation & purification Tablets - analysis TLC-determination TLC—determination, dapsone impurities in pharmaceutical preparations
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Beschreibung
Zusammenfassung:	Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4′‐diamino‐diphenyl sulfone and 4‐aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4′‐diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison with authentic compounds employing UV absorption, fluorometry, and mass spectrometry in addition to TLC and high‐pressure liquid chromatography.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600640717