Steroids IX: Synthesis of Some Thiazolosteroids

Steroids IX: Synthesis of Some Thiazolosteroids

The synthesis of thiazolo[d-3,2]-5α-cholest-2-ene, and thiazolo[d-3,2]-17α-methyl-5α-androst-2-en-17β-ol, and eight of their 2′-derivatives is reported. These derivatives include the 2′-methyl, 2′-amino, 2′-allylamino, and 2′-phenylamino substituted thiazolosteroids. Preliminary data indicate that 2...

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Veröffentlicht in:Journal of pharmaceutical sciences 1962-05, Vol.51 (5), p.414-417
Hauptverfasser: Doorenbos, Norman J., Dorn, Conrad P.
Format: Artikel
Sprache:eng
Schlagworte:
Old Medline
Steroids - chemistry
Thiazoles - chemistry
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Zusammenfassung:The synthesis of thiazolo[d-3,2]-5α-cholest-2-ene, and thiazolo[d-3,2]-17α-methyl-5α-androst-2-en-17β-ol, and eight of their 2′-derivatives is reported. These derivatives include the 2′-methyl, 2′-amino, 2′-allylamino, and 2′-phenylamino substituted thiazolosteroids. Preliminary data indicate that 2′-methylthiazolo[d-3,2]-17α methyl-5α-androst-2-en-17β-ol is a good anabolic agent.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600510504