Initiation of 3T3 fibroblast cell division by epidermal growth factor

Initiation of 3T3 fibroblast cell division by epidermal growth factor

Epidermal Growth Factor (EGF) at concentrations of 10−9 to 10−10 M initiates cell division in both confluent and low density non‐dividing 3T3 cells. Four days after addition of EGF to confluent or low density non‐dividing 3T3 cells there is a 2‐ and 5‐fold increase, respectively, in cell number....

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Veröffentlicht in:J. Cell. Physiol.; (United States) 1975-12, Vol.86 (S2), p.593-598
Hauptverfasser: Rose, Steven P., Pruss, Rebecca M., Herschman, Harvey R.
Format: Artikel
Sprache:eng
Schlagworte:
ANIMAL CELLS
BASIC BIOLOGICAL SCIENCES
Blood
BODY
Cell Count
CELL DIVISION
Cell Division - drug effects
Cell Line
Cell Survival
CONNECTIVE TISSUE CELLS
Culture Media
Dose-Response Relationship, Drug
EPIDERMIS
EPITHELIUM
FIBROBLASTS
GROWTH
Growth Substances - isolation & purification
Growth Substances - pharmacology
ORGANS
SKIN
SOMATIC CELLS
Thymidine - metabolism
TISSUES 550300 > Cytology
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Zusammenfassung:Epidermal Growth Factor (EGF) at concentrations of 10−9 to 10−10 M initiates cell division in both confluent and low density non‐dividing 3T3 cells. Four days after addition of EGF to confluent or low density non‐dividing 3T3 cells there is a 2‐ and 5‐fold increase, respectively, in cell number.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.1040860504