Ellipticine derivatives

Several acyloxy and alkyl derivatives of ellipticine have been prepared. In addition, a modified synthesis leading to the hitherto unobtainable 8,9-dimethoxy- and 8,9-methylenedioxyellipticines is described. Some of the derivatives described herein exhibit antitumor activity. However, none of the co...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1975-07, Vol.18 (7), p.755-760
Hauptverfasser:	Guthrie, Robert W, Brossi, Arnold, Mennona, Francis A, Mullin, John G, Kierstead, Richard W, Grunberg, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Animals Carcinoma, Ehrlich Tumor - drug therapy Ellipticines - chemical synthesis Ellipticines - therapeutic use Mice Sarcoma 180 - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Several acyloxy and alkyl derivatives of ellipticine have been prepared. In addition, a modified synthesis leading to the hitherto unobtainable 8,9-dimethoxy- and 8,9-methylenedioxyellipticines is described. Some of the derivatives described herein exhibit antitumor activity. However, none of the compounds showed activity superior to that of the naturally occurring pyridocarbazoles, ellipticine and 9-methoxyellipticine.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00241a023