Effect of Chlorothiazide on Response of Renal Vascular Bed to Vasoactive Substances

In the anesthetized dog, administration of an isosmotic solution of chlorothiazide into the renal artery failed to affect renal vascular resistance but did acutely attenuate the constriction produced by intra-arterial injection of l-epinephrine, levarterenol, and Val-5-angiotensin II and potentiated the dilation produced by intra-arterial injection of MgCl2.