Effects of certain indoleamines in the hippocampal-septal circuit

The effects of 5-HT and DMT upon the electrical activity in the lateral septal region, and region CA1 of the hippocampus, were studied in acutely prepared cats. Both 5-HT and DMT were found to have a facilitory effect on the firing of septal and hippocampal cells. Moreover, the facilitory effect of...

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Veröffentlicht in:	Experimental neurology 1975-08, Vol.48 (2), p.352-377
Hauptverfasser:	DeFrance, J.F., McCrea, R.A., Yoshihara, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - antagonists & inhibitors 5-Hydroxytryptophan - pharmacology Animals Bufotenin - pharmacology Cats Chlorpromazine - pharmacology Creatine - pharmacology Electrophysiology Hippocampus - drug effects Iontophoresis Membrane Potentials - drug effects N,N-Dimethyltryptamine - antagonists & inhibitors N,N-Dimethyltryptamine - pharmacology Norepinephrine - pharmacology Oxalates - pharmacology Septal Nuclei - drug effects Septum Pellucidum - drug effects Serotonin - pharmacology Stimulation, Chemical Sulfates - pharmacology Tryptamines - pharmacology Tryptophan - pharmacology
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Zusammenfassung:	The effects of 5-HT and DMT upon the electrical activity in the lateral septal region, and region CA1 of the hippocampus, were studied in acutely prepared cats. Both 5-HT and DMT were found to have a facilitory effect on the firing of septal and hippocampal cells. Moreover, the facilitory effect of 5-HT in the lateral septal region appeared to be the result of a depolarizing action upon the cell membrane. Methiothepin was found to be an effective blocker of the DMT and 5-HTP induced effect, but not the 5-HT induced effect.
ISSN:	0014-4886 1090-2430
DOI:	10.1016/0014-4886(75)90163-6