Data on the metabolism of benzylisoquinoline derivatives. The metabolism of drotaverin

Data on the metabolism of benzylisoquinoline derivatives. The metabolism of drotaverin

Studying the metabolism of drotaverin (No-Spa¿), we have elaborated a method for the isolation, purification and separation of metabolites and of drotaverin excreted in unchanged form in the urine and feces. The structure of the chief metabolites was cleared by t.l.c., polarography, UV spectrophotom...

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Veröffentlicht in:Pharmazie 1975-03, Vol.30 (3), p.174-177
Hauptverfasser: Gyarmati, L, Dávid, A, Mészáros, Z, Rácz, I, Szentmiklósi, P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Benzyl Compounds - metabolism
Benzyl Compounds - urine
Feces - analysis
Isoquinolines - metabolism
Isoquinolines - urine
Mass Spectrometry
Papaverine - analogs & derivatives
Papaverine - metabolism
Papaverine - urine
Rats
Spectrophotometry, Ultraviolet
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Zusammenfassung:Studying the metabolism of drotaverin (No-Spa¿), we have elaborated a method for the isolation, purification and separation of metabolites and of drotaverin excreted in unchanged form in the urine and feces. The structure of the chief metabolites was cleared by t.l.c., polarography, UV spectrophotometry, and mass spectrometry. It was stated that beside drotaverin excreted in unchanged form, the biotransformation of the molecule results in the formation of oxidation and desalkylation products.
ISSN:0031-7144