The heterogeneity and degradation of glucagon studied by polyacrylamide gel electrophoresis

The heterogeneity and degradation of glucagon studied by polyacrylamide gel electrophoresis

Polyacrylamide gel electrophoresis has been used to study the heterogeneity of glucagon, and changes in composition resulting from thermal degradation. The same technique can be employed, as a limit test, to monitor the amounts of insulin and desamidoglucagon in glucagon intended for therapeutic use...

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Veröffentlicht in:Journal of biological standardization 1975-01, Vol.3 (3), p.263,IN1,265-264,IN3,265
Hauptverfasser: Calam, D.H., Storring, P.L.
Format: Artikel
Sprache:eng
Schlagworte:
Deamination
Drug Stability
Electrophoresis, Polyacrylamide Gel
Glucagon - analysis
Glucagon - metabolism
Hot Temperature
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Zusammenfassung:Polyacrylamide gel electrophoresis has been used to study the heterogeneity of glucagon, and changes in composition resulting from thermal degradation. The same technique can be employed, as a limit test, to monitor the amounts of insulin and desamidoglucagon in glucagon intended for therapeutic use.
ISSN:0092-1157
DOI:10.1016/0092-1157(75)90028-1