Hemorrhagic Reactions at Sites of Passive Cutaneous Anaphylaxis in Guinea Pig after Intravenous Inoculation of Unrelated Immune Complex

Summary Experimental evidence is presented pointing to the prime importance of simultaneous anaphylactic sensitivity in development of hemorrhagic reactions of the Arthus-type in guinea pigs. A final conclusion as to the mechanism by which the local anaphylactic reaction enhances endothelial damage by intravenously injected immune complex requires further study. We are indebted to Dr. Z. Ovary for his valuable suggestions in preparation of this manuscript.