Antiallergic activity of .omega.-nitroacetophenones

Selected omega-nitroacetophenones, formed by the alcoholic cleavage of 2-nitroindandiones, have been shown to inhibit the homocytotropic antibody-antigen induced passive cutaneous analhylaxis reaction in the rat. The enzymatic cyclization of these derivatives to the parent nitroindandione has been d...

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Veröffentlicht in:	Journal of medicinal chemistry 1975-07, Vol.18 (7), p.733-736
Hauptverfasser:	Buckle, Derek R, Cantello, Barrie C. C, Morgan, Neil J, Smith, Harry, Spicer, Barbara A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - blood Acetophenones - chemical synthesis Acetophenones - therapeutic use Animals Cyclization Hypersensitivity - drug therapy In Vitro Techniques Liver - metabolism Nitro Compounds - blood Nitro Compounds - chemical synthesis Nitro Compounds - therapeutic use Passive Cutaneous Anaphylaxis Rats Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	Selected omega-nitroacetophenones, formed by the alcoholic cleavage of 2-nitroindandiones, have been shown to inhibit the homocytotropic antibody-antigen induced passive cutaneous analhylaxis reaction in the rat. The enzymatic cyclization of these derivatives to the parent nitroindandione has been demonstrated both in vivo and in vitro and this process is suggested as a possible prerequisite to biological activity.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00241a018