The protein and carbohydrate‐protein complexes of synovial fluids

Dialysis of normal and arthritic human synovial fluids at low ionic strength produced precipitates resembling the euglobulins of blood but often containing hyaluronic acid. Their compositions demonstrated the ability of hyaluronic acid to form insoluble complexes with globulins between pH 5.5 and 6.4, and with albumin at pH 5.5 when the concentration of globulins was low. Hyaluronic acid precipitated quantitatively at pH 4.4, but the percentage of hyaluronic acid increased with diminishing amounts of total precipitate between pH 4.4 and 2.6. Lo dialyse de liquido synovial ab humanos normal e arthritic a basse concentration ionic resultava in precipitatos resimilante le euglobulinas del sanguine sed continente, in multe casos, acido hyaluronic. Le composition de illos demonstrava le capacitate de acido hyaluronic de formar insolubile complexos con globulinas inter pH 5,5 e 6,4 e con albuminn a pH 5,5 quando le concentration del globulinas esseva basse. Acido hyaluronic se precipitava quantitativemente a pH 4,4, sed le procentage de acido hyaluronic cresceva con le declino quantitative del precipitato total inter pH 4,4 e 2,6.