The formation of histamine by fetal rat liver

The formation of histamine by fetal rat liver

Some of the characteristics of the histidine decarboxylase derived from fetal rat liver have been determined. The pH optimum is 6.6; pyridoxal 5'-phosphate is required as a coenzyme; the enzyme is not appreciably inhibited by a-methyl DOPA; and benzene neither activates nor inhibits the enzyme....

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Veröffentlicht in:Biochemical pharmacology 1962-01, Vol.11 (4), p.315-322
1. Verfasser: Burkhalter, Alan
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biochemical Phenomena
Fetus - metabolism
Histamine - metabolism
Liver - metabolism
Lyases - metabolism
Old Medline
Rats
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Zusammenfassung:Some of the characteristics of the histidine decarboxylase derived from fetal rat liver have been determined. The pH optimum is 6.6; pyridoxal 5'-phosphate is required as a coenzyme; the enzyme is not appreciably inhibited by a-methyl DOPA; and benzene neither activates nor inhibits the enzyme. The fetal enzyme activity appears shortly after the appearance of liver cells, reaches a peak at the fourteenth day of gestation and apparently disappears rapidly after birth. At the present time the functional significance of this enzyme remains obscure.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(62)90054-0