Renal adenylate cyclase activation by amino acylated vasopressin and oxytocin
Two series of neurohypophysial peptide amino-acylated derivatives were tested for their ability to activate plasma membrane adenylate cyclase prepared from pig or rat kidney. They were firstly [8-lysine]-vasopressin-related derivatives (N a[Glycyl-Cys] 1-[8-Lysine]-vasopressin and N a-[Glycyl-Glycyl...
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| Veröffentlicht in: | Molecular and cellular endocrinology 1975, Vol.2 (2), p.69-79 |
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| creator | Barth, Tomislav Roy, Christian Rajerison, Rabary Jard, Serge |
| description | Two series of neurohypophysial peptide amino-acylated derivatives were tested for their ability to activate plasma membrane adenylate cyclase prepared from pig or rat kidney. They were firstly [8-lysine]-vasopressin-related derivatives (N
a[Glycyl-Cys]
1-[8-Lysine]-vasopressin and N
a-[Glycyl-Glycyl-Glycyl-Cys]
1-[8-Lysine]-vasopressin) and secondly oxytocin-related derivatives (N
a-[Glycyl-Cys]
1-oxytocin, N
a-[Leucyl-Glycyl-Glycyl-Cys]
1-oxytocin, and N
a-[Glycyl-Cys]
1-[2-O-methyl tyrosine]-oxytocin). The maximal adenylate cyclase activation induced by these peptides was lower than that induced by their respective parent hormones. After incubation of these analogues with plasma membranes obtained from the renal medulla, no significant release of parent hormones occurred. Good qualitative correlations were observed between relative antidiuretic activities measured in vivo and relative potencies in activating adenylate cyclase. It was concluded that direct action of the peptides tested on the kidney is at least partly responsible for their antidiuretic activity in vivo. |
| doi_str_mv | 10.1016/0303-7207(75)90049-0 |
| format | Article |
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a[Glycyl-Cys]
1-[8-Lysine]-vasopressin and N
a-[Glycyl-Glycyl-Glycyl-Cys]
1-[8-Lysine]-vasopressin) and secondly oxytocin-related derivatives (N
a-[Glycyl-Cys]
1-oxytocin, N
a-[Leucyl-Glycyl-Glycyl-Cys]
1-oxytocin, and N
a-[Glycyl-Cys]
1-[2-O-methyl tyrosine]-oxytocin). The maximal adenylate cyclase activation induced by these peptides was lower than that induced by their respective parent hormones. After incubation of these analogues with plasma membranes obtained from the renal medulla, no significant release of parent hormones occurred. Good qualitative correlations were observed between relative antidiuretic activities measured in vivo and relative potencies in activating adenylate cyclase. It was concluded that direct action of the peptides tested on the kidney is at least partly responsible for their antidiuretic activity in vivo.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/0303-7207(75)90049-0</identifier><identifier>PMID: 1149916</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adenylyl Cyclases - metabolism ; amino-acylated neurohypophysial peptides ; Animals ; antidiuretic activity ; Cell Membrane - drug effects ; Cell Membrane - enzymology ; Diuresis - drug effects ; Dose-Response Relationship, Drug ; Enzyme Activation ; Kidney - enzymology ; Kidney Medulla - drug effects ; Kidney Medulla - enzymology ; Kidney Medulla - metabolism ; Kidney Medulla - ultrastructure ; Oxytocin - analogs & derivatives ; Oxytocin - metabolism ; Oxytocin - pharmacology ; Rats ; renal adenylate cyclase ; Swine ; Vasopressins - analogs & derivatives ; Vasopressins - pharmacology</subject><ispartof>Molecular and cellular endocrinology, 1975, Vol.2 (2), p.69-79</ispartof><rights>1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d7f2ade2d1910cfefbf0380c66f728894b10be4ba171e2439c624b7c090e11fd3</citedby><cites>FETCH-LOGICAL-c357t-d7f2ade2d1910cfefbf0380c66f728894b10be4ba171e2439c624b7c090e11fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0303-7207(75)90049-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,4014,27914,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1149916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barth, Tomislav</creatorcontrib><creatorcontrib>Roy, Christian</creatorcontrib><creatorcontrib>Rajerison, Rabary</creatorcontrib><creatorcontrib>Jard, Serge</creatorcontrib><title>Renal adenylate cyclase activation by amino acylated vasopressin and oxytocin</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>Two series of neurohypophysial peptide amino-acylated derivatives were tested for their ability to activate plasma membrane adenylate cyclase prepared from pig or rat kidney. They were firstly [8-lysine]-vasopressin-related derivatives (N
a[Glycyl-Cys]
1-[8-Lysine]-vasopressin and N
a-[Glycyl-Glycyl-Glycyl-Cys]
1-[8-Lysine]-vasopressin) and secondly oxytocin-related derivatives (N
a-[Glycyl-Cys]
1-oxytocin, N
a-[Leucyl-Glycyl-Glycyl-Cys]
1-oxytocin, and N
a-[Glycyl-Cys]
1-[2-O-methyl tyrosine]-oxytocin). The maximal adenylate cyclase activation induced by these peptides was lower than that induced by their respective parent hormones. After incubation of these analogues with plasma membranes obtained from the renal medulla, no significant release of parent hormones occurred. Good qualitative correlations were observed between relative antidiuretic activities measured in vivo and relative potencies in activating adenylate cyclase. It was concluded that direct action of the peptides tested on the kidney is at least partly responsible for their antidiuretic activity in vivo.</description><subject>Adenylyl Cyclases - metabolism</subject><subject>amino-acylated neurohypophysial peptides</subject><subject>Animals</subject><subject>antidiuretic activity</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - enzymology</subject><subject>Diuresis - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Activation</subject><subject>Kidney - enzymology</subject><subject>Kidney Medulla - drug effects</subject><subject>Kidney Medulla - enzymology</subject><subject>Kidney Medulla - metabolism</subject><subject>Kidney Medulla - ultrastructure</subject><subject>Oxytocin - analogs & derivatives</subject><subject>Oxytocin - metabolism</subject><subject>Oxytocin - pharmacology</subject><subject>Rats</subject><subject>renal adenylate cyclase</subject><subject>Swine</subject><subject>Vasopressins - analogs & derivatives</subject><subject>Vasopressins - pharmacology</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LxDAQxYMo67r6HyjkJHqoTtKPNBdBFr9gRRA9hzSZQqSbrE13sf-93a3ozdPAmzfvMT9CThlcMWDFNaSQJoKDuBD5pQTIZAJ7ZMpKwZMScrFPpr-WQ3IU4wcAiJyXEzJhLJOSFVPy_IpeN1Rb9H2jO6SmN42OSLXp3EZ3Lnha9VQvnQ-DtvNYutExrFqM0XmqvaXhq--Ccf6YHNS6iXjyM2fk_f7ubf6YLF4enua3i8SkuegSK2o-NHLLJANTY13VkJZgiqIWvCxlVjGoMKs0Ewx5lkpT8KwSBiQgY7VNZ-R8zF214XONsVNLFw02jfYY1lGVXPI0Z8VgzEajaUOMLdZq1bqlbnvFQG0pqi0itUWkRK52FAdpRs5-8tfVEu3f0Yht2N-Mexye3DhsVTQOvUHrWjSdssH9X_ANawmB0Q</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>Barth, Tomislav</creator><creator>Roy, Christian</creator><creator>Rajerison, Rabary</creator><creator>Jard, Serge</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1975</creationdate><title>Renal adenylate cyclase activation by amino acylated vasopressin and oxytocin</title><author>Barth, Tomislav ; Roy, Christian ; Rajerison, Rabary ; Jard, Serge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d7f2ade2d1910cfefbf0380c66f728894b10be4ba171e2439c624b7c090e11fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adenylyl Cyclases - metabolism</topic><topic>amino-acylated neurohypophysial peptides</topic><topic>Animals</topic><topic>antidiuretic activity</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - enzymology</topic><topic>Diuresis - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Activation</topic><topic>Kidney - enzymology</topic><topic>Kidney Medulla - drug effects</topic><topic>Kidney Medulla - enzymology</topic><topic>Kidney Medulla - metabolism</topic><topic>Kidney Medulla - ultrastructure</topic><topic>Oxytocin - analogs & derivatives</topic><topic>Oxytocin - metabolism</topic><topic>Oxytocin - pharmacology</topic><topic>Rats</topic><topic>renal adenylate cyclase</topic><topic>Swine</topic><topic>Vasopressins - analogs & derivatives</topic><topic>Vasopressins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barth, Tomislav</creatorcontrib><creatorcontrib>Roy, Christian</creatorcontrib><creatorcontrib>Rajerison, Rabary</creatorcontrib><creatorcontrib>Jard, Serge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barth, Tomislav</au><au>Roy, Christian</au><au>Rajerison, Rabary</au><au>Jard, Serge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal adenylate cyclase activation by amino acylated vasopressin and oxytocin</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>1975</date><risdate>1975</risdate><volume>2</volume><issue>2</issue><spage>69</spage><epage>79</epage><pages>69-79</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>Two series of neurohypophysial peptide amino-acylated derivatives were tested for their ability to activate plasma membrane adenylate cyclase prepared from pig or rat kidney. They were firstly [8-lysine]-vasopressin-related derivatives (N
a[Glycyl-Cys]
1-[8-Lysine]-vasopressin and N
a-[Glycyl-Glycyl-Glycyl-Cys]
1-[8-Lysine]-vasopressin) and secondly oxytocin-related derivatives (N
a-[Glycyl-Cys]
1-oxytocin, N
a-[Leucyl-Glycyl-Glycyl-Cys]
1-oxytocin, and N
a-[Glycyl-Cys]
1-[2-O-methyl tyrosine]-oxytocin). The maximal adenylate cyclase activation induced by these peptides was lower than that induced by their respective parent hormones. After incubation of these analogues with plasma membranes obtained from the renal medulla, no significant release of parent hormones occurred. Good qualitative correlations were observed between relative antidiuretic activities measured in vivo and relative potencies in activating adenylate cyclase. It was concluded that direct action of the peptides tested on the kidney is at least partly responsible for their antidiuretic activity in vivo.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>1149916</pmid><doi>10.1016/0303-7207(75)90049-0</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-7207 |
| ispartof | Molecular and cellular endocrinology, 1975, Vol.2 (2), p.69-79 |
| issn | 0303-7207 1872-8057 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82923516 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenylyl Cyclases - metabolism amino-acylated neurohypophysial peptides Animals antidiuretic activity Cell Membrane - drug effects Cell Membrane - enzymology Diuresis - drug effects Dose-Response Relationship, Drug Enzyme Activation Kidney - enzymology Kidney Medulla - drug effects Kidney Medulla - enzymology Kidney Medulla - metabolism Kidney Medulla - ultrastructure Oxytocin - analogs & derivatives Oxytocin - metabolism Oxytocin - pharmacology Rats renal adenylate cyclase Swine Vasopressins - analogs & derivatives Vasopressins - pharmacology |
| title | Renal adenylate cyclase activation by amino acylated vasopressin and oxytocin |
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