Spontaneous Remodeling of the Peripheral Retinal Vasculature in Sickling Disorders

Periodic photographic and angiographic surveys of patients with the earliest stages of sickle retinopathy showed a number of fundus findings. In seven cases (sickle cell anemia, four; sickle cell hemoglobin C, three), these findings included: (1) a variety of vascular abnormalities in the equatorial...

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Veröffentlicht in:American journal of ophthalmology 1975-05, Vol.79 (5), p.853-870
Hauptverfasser: Galinos, Spiros O., Asdourian, George K., Woolf, Michael B., Stevens, Thomas S., Lee, Chang-Bok, Goldberg, Morton F., Chow, Joseph C.F., Busse, Bruce J.
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Sprache:eng
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Zusammenfassung:Periodic photographic and angiographic surveys of patients with the earliest stages of sickle retinopathy showed a number of fundus findings. In seven cases (sickle cell anemia, four; sickle cell hemoglobin C, three), these findings included: (1) a variety of vascular abnormalities in the equatorial and post-equatorial retina such as segmented dilations of the vessel walls, hairpin-shaped vascular loops, hypertrophic, tortuous A-V anastomoses, intraluminal plugs, closure and loss of capillary bed, and terminal budding of capillaries; and (2) a continuous, spontaneous remodeling of the peripheral retinal vasculature due to successive closures and reopenings of equatorial retinal vessels. A centripetal recession of the peripheral retinal vasculature usually resulted. No correlation between the ophthalmoscopic and the systemic condition of the patients could be made.
ISSN:0002-9394
1879-1891
DOI:10.1016/0002-9394(75)90747-3