Selection of a Reference Partitioning System for Drug Design Work

Consideration of the structural, polar, and transport properties of water‐saturated solvent and solvent‐saturated water phases of three general and eight specific binary systems leads to the conclusion that the n‐octanol—water system is a very good allround compromise for use as a reference system f...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1975-04, Vol.64 (4), p.599-606
Hauptverfasser:	Smith, R. Nelson, Hansch, Copwin, Ames, Matthew M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols and transport properties of solvent and water phases Biological partitioning-reference systems Biological partitioning—reference systems, structural, polar, and transport properties of solvent and water phases Chemical Phenomena Chemistry Esters Magnetic Resonance Spectroscopy n-octanol-water system and others Partitioning systems-selection of a reference for drug design work Partitioning systems—selection of a reference for drug design work, structural, polar, and transport properties of solvent and water phases, n‐octanol—water system and others Pharmaceutical Preparations polar Solubility Solvents Spectrophotometry, Infrared structural Temperature Thermodynamics Transport-selection of a reference partitioning system for drug design work Viscosity Water
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Beschreibung
Zusammenfassung:	Consideration of the structural, polar, and transport properties of water‐saturated solvent and solvent‐saturated water phases of three general and eight specific binary systems leads to the conclusion that the n‐octanol—water system is a very good allround compromise for use as a reference system for biological partitioning in drug design work.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600640405