Bile acids secretion and synthesis by isolated rat hepatocytes

Bile acids secretion and synthesis by isolated rat hepatocytes

Bile acids secretion and their distribution were studied in isolated rat hepatocytes. Bile acids secretion was linearly related with time for first three hours of incubation and the net secretion rate was 23.2 ± 2.74 nmoles per g cells (wet weight) per minute. Isolated hepatocytes synthesized relati...

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Veröffentlicht in:Biochemical and biophysical research communications 1975-05, Vol.64 (2), p.603-609
Hauptverfasser: Anwer, M.S., Kroker, R., Hegner, D.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bile Acids and Salts - biosynthesis
Bile Acids and Salts - metabolism
Chenodeoxycholic Acid - biosynthesis
Cholic Acids - biosynthesis
Liver - cytology
Liver - metabolism
Male
Rats
Time Factors
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Zusammenfassung:Bile acids secretion and their distribution were studied in isolated rat hepatocytes. Bile acids secretion was linearly related with time for first three hours of incubation and the net secretion rate was 23.2 ± 2.74 nmoles per g cells (wet weight) per minute. Isolated hepatocytes synthesized relatively more chenodeoxycholic acid than cholic acid compared to whole animal. These results suggest that isolated hepatocytes synthesize and secrete bile acids and thus provide experimental system to study the effect of drugs on bile acids secretion and synthesis at cellular level.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(75)90364-2