A model of thymocyte proliferation

A model of thymocyte proliferation

A steady-state model, based upon an analytical approach to the interpretation pf thymic radioautographic data is presented. In the model the process of cellular proliferation is represented by a feedback amplifier. It is shown by computer simulation that a model based on this conception, in which ce...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of theoretical biology 1975-06, Vol.51 (2), p.357-382
Hauptverfasser: Prothero, John W., Tyler, Ruth W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Autoradiography
Biometry
Cell Movement
DNA - biosynthesis
Feedback
Lymphocytes
Male
Mitosis
Models, Biological
Rats
Stochastic Processes
Thymus Gland - cytology
Time Factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A steady-state model, based upon an analytical approach to the interpretation pf thymic radioautographic data is presented. In the model the process of cellular proliferation is represented by a feedback amplifier. It is shown by computer simulation that a model based on this conception, in which cellular flow through G 1 compartments is treated as a stochastic process and that through the S, G2 and M compartments by a sequential unidirectional process, is in reasonable agreement with the experimental data.
ISSN:0022-5193
1095-8541
DOI:10.1016/0022-5193(75)90066-1