Response to hypercapnia under ketamine anaesthesia

The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased. This respiratory stimulation was most probably due to a direct effect of the drug on the medullary respiratory neurones. This effect was not modified by preanaesthetic medication pentobarbitone 5 mg/kg or morp...

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Veröffentlicht in:	Canadian Anaesthetists' Society journal 1975-07, Vol.22 (4), p.486-494
Hauptverfasser:	Soliman, M G, Brindle, G F, Kuster, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium Anesthesia, Intravenous Animals Atropine Blood Pressure - drug effects Carbon Dioxide - blood Catecholamines - blood Central Venous Pressure - drug effects Dogs Hypercapnia - physiopathology Ketamine - antagonists & inhibitors Ketamine - pharmacology Morphine Oxygen - blood Pentobarbital Preanesthetic Medication Respiration - drug effects Space life sciences
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Beschreibung
Zusammenfassung:	The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased. This respiratory stimulation was most probably due to a direct effect of the drug on the medullary respiratory neurones. This effect was not modified by preanaesthetic medication pentobarbitone 5 mg/kg or morphine 0.1 mg/kg. Catecholamine response to hypercapnia was essentially the same as that reported by hypercapnic dogs anaesthetized with thiopentone.
ISSN:	0008-2856 1496-8975
DOI:	10.1007/BF03004864