Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides

The binding of concanavalin A to T but not B mouse spleen lymphocytes increases Ca 2+ uptake in these cells which is measurable by 45 s and complete by 1 min. Dibutyryl cyclic AMP, but not sodium azide inhibits induced Ca 2+ uptake, whereas dibutyryl cyclic GMP enhances it. B cell mitogens do not ca...

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Veröffentlicht in:	Nature (London) 1975-05, Vol.255 (5507), p.378-382
Hauptverfasser:	Freedman, Murray H., Raff, Martin C., Gomperts, Bastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azides - pharmacology B-Lymphocytes - metabolism Bucladesine - pharmacology Calcium - metabolism Carbon Radioisotopes Cell Division - drug effects Cell Membrane Permeability - drug effects Concanavalin A - pharmacology Cyclic AMP - pharmacology Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Cytosol - metabolism Depression, Chemical Humanities and Social Sciences Humans Mice Mice, Inbred BALB C Mitogens - pharmacology multidisciplinary Science Science (multidisciplinary) Spleen Stimulation, Chemical T-Lymphocytes - metabolism
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Zusammenfassung:	The binding of concanavalin A to T but not B mouse spleen lymphocytes increases Ca 2+ uptake in these cells which is measurable by 45 s and complete by 1 min. Dibutyryl cyclic AMP, but not sodium azide inhibits induced Ca 2+ uptake, whereas dibutyryl cyclic GMP enhances it. B cell mitogens do not cause a similar Ca 2+ uptake in mouse B lymphocytes. The induction of increased Ca 2+ uptake by T cells is discussed in terms of gated membrane channels for Ca 2+ .
ISSN:	0028-0836 1476-4687
DOI:	10.1038/255378a0