Studies on the effect of 2-hydroxy-5-nitrobenzyl bromide on the mechanism of insulin

Studies on the effect of 2-hydroxy-5-nitrobenzyl bromide on the mechanism of insulin

The effects of HNB were tested on the binding of insulin to fat cells and fat cell membranes as well as the responsiveness of fat cells to insulin. Although metabolism was found to be inhibited, the reagent was found to stimulate the binding of insulin. The stimulatory effect on insulin binding as w...

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Veröffentlicht in:Life sciences (1973) 1975-02, Vol.16 (3), p.415-422
Hauptverfasser: Maturo, J.M., Siegel, G., Furino, C.
Format: Artikel
Sprache:eng
Schlagworte:
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Animals
Benzyl Compounds - pharmacology
Binding Sites
Carbon Radioisotopes
Cell Membrane - drug effects
Cell Membrane - metabolism
Cell Separation
Concanavalin A - pharmacology
Depression, Chemical
Insulin - metabolism
Nitrophenols - pharmacology
Rats
Receptors, Cell Surface
Stimulation, Chemical
Tryptophan - pharmacology
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Zusammenfassung:The effects of HNB were tested on the binding of insulin to fat cells and fat cell membranes as well as the responsiveness of fat cells to insulin. Although metabolism was found to be inhibited, the reagent was found to stimulate the binding of insulin. The stimulatory effect on insulin binding as well as inhibitory effect on metabolism was reversed by free tryptophan consumption of the reagent. The results are discussed relative to these findings.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(75)90262-3