Experiences with large infusions of gamma globulin

The possible clinical applications for large infusions of gamma globulin have been discussed. Our data confirms that of Moore and Amos with respect to the absence of chemotherapeutic value of pooled gamma globulin in patients with far advanced malignancy. Of greatest practical importance, at present, is the use of gamma globulin as a potential source of specific antibody against organisms producing infections refractory to therapy with antibiotics alone; an apparent therapeutic benefit in one such case is reported. The definitive cause and method for suppression of colloidal reactions to infusions of this agent have not yet been found. Since these reactions have not produced any serious sequellae to date, we see no objection to the cautious intravenous infusion of gamma globulin in patients with refractory infections. The addition of albumin to the infusion may have a favorable effect on reduction of the incidence and severity of reactions. The reciprocal fall in the level of albumin secondary to the elevation in the level of circulating gamma globulin presents an interesting theoretic implication with respect to factors controlling the level of circulating plasma proteins.