NMR evidence for common tertiary structure base pairs in yeast and E. coli tRNA

ABOUT ten years ago Holley 1 and coworkers sequenced the first tRNA and proposed the now famous cloverleaf secondary structure. Since that time about sixty additional tRNAs have been sequenced and all fit the cloverleaf model 2 . This homology constitutes a strong case for the cloverleaf model and t...

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Veröffentlicht in:	Nature (London) 1975-05, Vol.255 (5506), p.347-349
Hauptverfasser:	BOLTON, PHILIP H, KEARNS, DAVID R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Escherichia coli - analysis Humanities and Social Sciences letter Magnesium Magnetic Resonance Spectroscopy multidisciplinary Nucleic Acid Conformation RNA, Transfer - analysis Science Science (multidisciplinary) Yeasts - analysis
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Beschreibung
Zusammenfassung:	ABOUT ten years ago Holley 1 and coworkers sequenced the first tRNA and proposed the now famous cloverleaf secondary structure. Since that time about sixty additional tRNAs have been sequenced and all fit the cloverleaf model 2 . This homology constitutes a strong case for the cloverleaf model and there is now compelling evidence from nuclear magnetic resonance (NMR) studies 3 that the clover-leaf model does provide a correct description of the secondary structure of tRNA molecules in solution.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/255347a0