Decomposition of p‐Aminosalicylic Acid in the Solid State

Aminosalicylic acid was used as a test substance to show that a solid‐state decomposition governed by nucleation kinetics can give rise to first‐order kinetics. The effect of sorbed moisture at a low degree of coverage was tested. Sorbed moisture theories proposed previously apply when it is realize...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1975-01, Vol.64 (1), p.37-44
Hauptverfasser:	Carstensen, J.T., Pothisiri, Pakdee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminosalicylic acid-decomposition in the solid state Aminosalicylic Acids Aminosalicylic acid—decomposition in the solid state, first‐order decomposition patterns Chemical Phenomena Chemistry Decomposition-aminosalicylic acid in solid state giving rise to first-order kinetics Decomposition—aminosalicylic acid in solid state giving rise to first‐order kinetics, sorbed moisture theories discussed Drug Stability first-order decomposition patterns Humidity Kinetics Manometry Moisture-decomposition of aminosalicylic acid in solid state Oxygen Solubility sorbed moisture theories discussed Stability-decomposition of aminosalicylic acid in solid state Stability—decomposition of aminosalicylic acid in solid state, sorbed moisture theories discussed, first‐order decomposition patterns Surface Properties Temperature Water - analysis
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