Decomposition of p‐Aminosalicylic Acid in the Solid State

Aminosalicylic acid was used as a test substance to show that a solid‐state decomposition governed by nucleation kinetics can give rise to first‐order kinetics. The effect of sorbed moisture at a low degree of coverage was tested. Sorbed moisture theories proposed previously apply when it is realize...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of pharmaceutical sciences 1975-01, Vol.64 (1), p.37-44
Hauptverfasser: Carstensen, J.T., Pothisiri, Pakdee
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aminosalicylic acid was used as a test substance to show that a solid‐state decomposition governed by nucleation kinetics can give rise to first‐order kinetics. The effect of sorbed moisture at a low degree of coverage was tested. Sorbed moisture theories proposed previously apply when it is realized that the rate constants in the presence of the sorbed layer may differ from the values of these parameters under anhydrous conditions.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600640107