Decomposition of p‐Aminosalicylic Acid in the Solid State
Aminosalicylic acid was used as a test substance to show that a solid‐state decomposition governed by nucleation kinetics can give rise to first‐order kinetics. The effect of sorbed moisture at a low degree of coverage was tested. Sorbed moisture theories proposed previously apply when it is realize...
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Veröffentlicht in: | Journal of pharmaceutical sciences 1975-01, Vol.64 (1), p.37-44 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Aminosalicylic acid was used as a test substance to show that a solid‐state decomposition governed by nucleation kinetics can give rise to first‐order kinetics. The effect of sorbed moisture at a low degree of coverage was tested. Sorbed moisture theories proposed previously apply when it is realized that the rate constants in the presence of the sorbed layer may differ from the values of these parameters under anhydrous conditions. |
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ISSN: | 0022-3549 1520-6017 |
DOI: | 10.1002/jps.2600640107 |