Antiatherosclerotic and Anticoagulant Activity of Cerebroside Sulfate

(1) Oral administration of crude cerebroside extracted from bovine brain inhibited the diet-induced elevation of serum cholesterol in the rabbit. Both purified cerebroside and sphingomyelin showed similar and less effect. (2) Intravenously administered cerebroside and cerebroside sulfate proved to have hypocholesteremic effect. The latter significantly inhibited atheromatous involvements in the aorta. (3) Cerebroside sulfate increased fecal excretion of digitonin-precipitable, Liebermann-Burchard-positive sterols by intravenous administration. (4) Cerebroside sulfate inhibited both thromboplastin generation and thrombin-fibrinogen reaction.