Iron deficiency anemia and increased urinary norepinephrine excretion

Iron deficiency anemia and increased urinary norepinephrine excretion

Chronic iron deficiency in rats resulted in decreased MAO activity both in vitro and in vivo. Since MAO is an important enzyme in inactivation of catecholamines, urinary excretion of DA, NE, E, MN-NMN, and VMA was measured in 24-hour samples from 11 iron-deficient children before and after treatment...

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Veröffentlicht in:The Journal of pediatrics 1975-04, Vol.86 (4), p.542-547
Hauptverfasser: Voorhess, Mary L., Stuart, Marie J., Stockman, James A., Oski, Frank A.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Anemia, Hypochromic - therapy
Anemia, Hypochromic - urine
Blood Transfusion
Blood Volume
Child, Preschool
Dopamine - urine
Epinephrine - urine
Female
Hemoglobins - analysis
Humans
Infant
Iron - blood
Iron-Dextran Complex - therapeutic use
Male
Metanephrine - urine
Norepinephrine - urine
Normetanephrine - urine
Vanilmandelic Acid - urine
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Zusammenfassung:Chronic iron deficiency in rats resulted in decreased MAO activity both in vitro and in vivo. Since MAO is an important enzyme in inactivation of catecholamines, urinary excretion of DA, NE, E, MN-NMN, and VMA was measured in 24-hour samples from 11 iron-deficient children before and after treatment with intramuscular iron. Pretreatment NE excretion was abnormally high and returned to normal (P=0.001) within one week of therapy. VMA excretion also was higher before than after treatment (P
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(75)80144-2