The visualization of receptors for the Fc portion of the IgG molecule on human neutrophil leukocytes

The visualization of receptors for the Fc portion of the IgG molecule on human neutrophil leukocytes

Human neutrophils treated with either Fc or with intact IgG and subsequently with fluorescein-labelled anti-IgG showed binding of the Fc or the IgG to the cell membrane. Neutrophils did not appear to bind F(ab′) 2 fragments. Under suitable conditions, polar capping of fluorescence was seen. The data...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Life sciences (1973) 1974-06, Vol.14 (12), p.2427-2430
Hauptverfasser: Sajnani, Ashok N., Ranadive, Narendranath S., Movat, Henry Z.
Format: Artikel
Sprache:eng
Schlagworte:
Fluorescent Antibody Technique
Glucuronidase - metabolism
Humans
Immunoglobulin G - metabolism
Neutrophils - immunology
Receptor Aggregation
Receptors, Fc - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Human neutrophils treated with either Fc or with intact IgG and subsequently with fluorescein-labelled anti-IgG showed binding of the Fc or the IgG to the cell membrane. Neutrophils did not appear to bind F(ab′) 2 fragments. Under suitable conditions, polar capping of fluorescence was seen. The data suggest receptors for Fc on the neutrophil membrane and mobility of these receptors.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(74)90138-6