Reversible Restoration by Thymosin of Antigen-Induced Depression of Spleen DNA Synthesis in NZB Mice
Antigen-induced depression of spleen DNA synthesis was studied in NZB and CBA/J mice. This phenomenon, a measure of T suppressor cell activity, normally decreases as a consequence of aging. However, NZB mice have an accelerated loss of antigen-induced depression that can be restored by treatment wit...
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Veröffentlicht in: | The Journal of immunology (1950) 1975-06, Vol.114 (6), p.1713-1716 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Antigen-induced depression of spleen DNA synthesis was studied in NZB and CBA/J mice. This phenomenon, a measure of T suppressor cell activity, normally decreases as a consequence of aging. However, NZB mice have an accelerated loss of antigen-induced depression that can be restored by treatment with thymosin or injection of 1-month-old NZB thymocytes. The restoration by thymosin declined between 1 and 2 weeks after treatment, but could be induced again after a second exposure to thymosin. These results suggest a potential for reversible but repeatable restoration of suppressor cell activity in NZB mice. |
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ISSN: | 0022-1767 1550-6606 |
DOI: | 10.4049/jimmunol.114.6.1713 |