Reversible Restoration by Thymosin of Antigen-Induced Depression of Spleen DNA Synthesis in NZB Mice

Antigen-induced depression of spleen DNA synthesis was studied in NZB and CBA/J mice. This phenomenon, a measure of T suppressor cell activity, normally decreases as a consequence of aging. However, NZB mice have an accelerated loss of antigen-induced depression that can be restored by treatment wit...

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Veröffentlicht in:The Journal of immunology (1950) 1975-06, Vol.114 (6), p.1713-1716
Hauptverfasser: Dauphinee, Michael J, Talal, Norman
Format: Artikel
Sprache:eng
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Zusammenfassung:Antigen-induced depression of spleen DNA synthesis was studied in NZB and CBA/J mice. This phenomenon, a measure of T suppressor cell activity, normally decreases as a consequence of aging. However, NZB mice have an accelerated loss of antigen-induced depression that can be restored by treatment with thymosin or injection of 1-month-old NZB thymocytes. The restoration by thymosin declined between 1 and 2 weeks after treatment, but could be induced again after a second exposure to thymosin. These results suggest a potential for reversible but repeatable restoration of suppressor cell activity in NZB mice.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.114.6.1713