Radioprotection by Mitotic Inhibitors and Mercaptoethylamine

In the mouse, chemical interference with cellular proliferation alters the radiosensitivity of the bone marrow, and this results in protection from otherwise lethal x-irradiation. When intestinal damage is minimized by appropriate timing and dosage, many mitotic inhibitors increase radioresistance a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1961-03, Vol.133 (3456), p.888-888
Hauptverfasser:	Rothe, William E., Grenan, Marie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMINES Animals BIOLOGY AND MEDICINE BONE MARROW Cell Division - pharmacology CHEMICALS Cysteamine Dosage INTESTINE LETHAL DOSE Mercaptoethylamines - pharmacology MICE MITOSIS Old Medline Radiation dosage RADIATION PROTECTION Radiation tolerance RADIOSENSITIVITY X RADIATION X-Rays
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Beschreibung
Zusammenfassung:	In the mouse, chemical interference with cellular proliferation alters the radiosensitivity of the bone marrow, and this results in protection from otherwise lethal x-irradiation. When intestinal damage is minimized by appropriate timing and dosage, many mitotic inhibitors increase radioresistance and enhance the protective effects of mercaptoethylamine.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.133.3456.888